A new asymmetric synthesis of trans-hydroisoquinolones |
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| Authors: | Kamatani A Overman L E |
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| Institution: | Department of Chemistry, 516 Rowland Hall, University of California, Irvine, California 92697-2025, USA. |
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| Abstract: | reaction: see text]. A convenient enantioselective synthesis of trans-hydroisoquinolones is described. This synthesis capitalizes on the ready availability of enantioenriched 2-substituted cyclohexenols by exploiting the asymmetry of an allylic carbon-oxygen sigma bond to control carbon-carbon bond formation in pinacol-terminated cyclizations of N-acyliminium cations. |
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