Studies toward the total synthesis of the cytotoxic sponge alkaloid pyrinodemin A |
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| Authors: | Baldwin J E Romeril S P Lee V Claridge T D |
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| Institution: | The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK. jack.baldwin@chem.ox.ac.uk |
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| Abstract: | structure: see text]. The syntheses of the proposed structure of pyrinodemin A (1) and its cis double bond positional isomer (C15'-C16') in racemic form are described. The key reaction involved an intramolecular nitrone/double bond cycloaddition. Our results suggest that neither 1 nor its double positional isomer is the correct structure of pyrinodemin A |
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