Enantioselective copper-catalyzed allylic alkylation with dialkylzincs using phosphoramidite ligands |
| |
Authors: | Malda H van Zijl A W Arnold L A Feringa B L |
| |
Institution: | Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. |
| |
Abstract: | reaction: see text]. In the presence of a catalytic amount of copper salts, cinnamyl halides undergo a regio- and enantioselective S(N)2' alkylation with dialkylzincs using chiral phosphoramidites as ligands. An S(N)2':S(N)2 ratio of 85:15 and enantiomeric excesses up to 77% for the chiral S(N)2' products are found. Variation of solvent and reaction temperature revealed that the highest regio- and enantioselectivities are found using coordinating solvents of -40 degrees C. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|