Synthesis of a sulfahydantoin library |
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Authors: | Albericio F Bryman L M Garcia J Michelotti E L Nicolás E Tice C M |
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Institution: | Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain. |
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Abstract: | A five-step solid-phase synthesis of sulfahydantoins from alpha-amino acids and aldehydes was developed. The synthetic method allows the use of hindered amino acids, including Val, Phg, and Aib, and use of aromatic aldehydes substituted with electron-withdrawing and -donating groups. Some limitations were encountered with amino acids with reactive side chains. A small but diverse library of compounds was produced for biological testing. |
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