Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition |
| |
| Authors: | Kokotos Christoforos G Limnios Dimitris Triggidou Despoina Trifonidou Maria Kokotos George |
| |
| Institution: | Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, 15771, Athens, Greece. |
| |
| Abstract: | The synthesis of novel organocatalysts consisting of a pyrrolidine moiety and a thiohydantoin or a thioxotetrahydropyrimidinone ring is described. The compound combining the pyrrolidine with the thioxotetrahydropyrimidinone was found to be a highly effective catalyst for the Michael reaction. Low catalyst loadings (1-2.5%) can be employed leading to quantitative yields and excellent stereoselectivities in the reaction between cyclic ketones and nitroolefins. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
