A label-free DNA reduced graphene oxide-based fluorescent sensor for highly sensitive and selective detection of hemin |
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| Authors: | Shi Yan Huang Wei Tao Luo Hong Qun Li Nian Bing |
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| Institution: | Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. |
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| Abstract: | G-quadruplex structure aptamer (PS2.M) can capture acridine orange (AO) from reduced graphene oxide (rGO). When the AO-PS2.M/rGO mixture is incubated with hemin, the specific binding of hemin with PS2.M results in a release of AO from PS2.M and return of AO back to rGO. Based on the quenching of fluorescence, the target hemin was detected sensitively and selectively, giving a detection limit of 50 nM. |
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