Cross-couplings of unactivated secondary alkyl halides: room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides |
| |
Authors: | Zhou Jianrong Steve Fu Gregory C |
| |
Affiliation: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
| |
Abstract: | The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|