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Superacid-catalyzed Friedel-Crafts cyclization of unactivated alkenes |
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| Authors: | Sara A. BonderoffF.G. West Martin Tremblay |
| Affiliation: | a Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2 b Boehringer Ingelheim (Canada) Ltd, 2100 rue Cunard, Laval, QC, Canada H7S 2G5 |
| Abstract: | Trifluoromethanesulfonimide is an effective catalyst for Friedel-Crafts cyclizations of simple, nonpolarized alkenes with a variety of pendant arenes. A catalyst loading of 0.5 - 1.0 mol % effects clean cyclization to form 5- to 7-membered carbocycles with generally short reaction times and good to excellent yields under reflux or microwave heating. |
| Keywords: | Friedel-Crafts alkylation Trifluoromethanesulfonimide Tetralin synthesis Unactivated alkene Superacid |
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