Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis |
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| Authors: | Salvino J M Kumar N V Orton E Airey J Kiesow T Crawford K Mathew R Krolikowski P Drew M Engers D Krolikowski D Herpin T Gardyan M McGeehan G Labaudiniere R |
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| Institution: | Lead Discovery Department, Rhone Poulen Rorer, Collegeville, Pennsylvania 19426, USA. |
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| Abstract: | A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis. |
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