N-Dealkylation of Amines |
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Authors: | Ali Alipour Najmi Rainer Bischoff Hjalmar P Permentier |
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Institution: | Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands; (A.A.N.); (R.B.) |
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Abstract: | N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this review, different approaches for the N-dealkylation of amines including chemical, catalytic, electrochemical, photochemical and enzymatic methods will be discussed. |
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Keywords: | N-dealkylation opiate alkaloids drug metabolite tropane alkaloids |
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