The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity |
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| Authors: | Jinyan Tan Yangang Cheng Shihui Wang Jianli Li Haiqin Ren Yuanbiao Qiao Qingshan Li Yingli Wang |
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| Institution: | 1.Shanxi Modern Chinese Medicine Engineering Laboratory, Shanxi University of Chinese Medicine, Jinzhong 030619, China; (J.T.); (Y.C.); (S.W.); (J.L.); (H.R.);2.Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Jinzhong 030619, China; |
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| Abstract: | In our current investigation, 37 constituents (1–37), including 11 megastigmanes (1–11), 17 flavonoids (12–28) and 9 phenylpropanoids (29–37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus. Among them, compounds 1–3, 12 and 29 were new compounds and their structures were elucidated on the basis of physicochemical evidence and meticulous spectroscopic analysis (NMR, HRESIMS and CD). Compounds 13, 16, 21 and 28 showed moderate inhibitory effect on α-glycosidase inhibitory activities, with IC50 values being in the range of 29.47–54.82 µM and stronger than the positive control (acarbose, 60.01 ± 4.82 µM). |
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| Keywords: | walnut megastigmanes bicyclic neomegastigmane flavonoids phenylpropanoids α -glucosidase inhibition activity |
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