The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide,Bifunctional Chelator,and Pharmacokinetics Modifying Linker |
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| Authors: | Holis Abdul Holik Faisal Maulana Ibrahim Angela Alysia Elaine Bernap Dwi Putra Arifudin Achmad Achmad Hussein Sundawa Kartamihardja |
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| Institution: | 1.Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia; (F.M.I.); (A.A.E.); (B.D.P.);2.Department of Nuclear Medicine and Molecular Theranostics, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung 40161, Indonesia; (A.A.); (A.H.S.K.);3.Oncology and Stem Cell Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia |
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| Abstract: | Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher. |
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| Keywords: | radiopharmaceuticals theranostics radionuclide chelator pharmacokinetic-modifying linker |
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