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Construction of Smart Stimuli-Responsive DNA Nanostructures for Biomedical Applications |
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| Authors: | Huimin Wang Dan Luo Hong Wang Prof. Fuan Wang Prof. Xiaoqing Liu |
| Affiliation: | 1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430000 P. R. China College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, 443002 P. R. China These authors contributed equally to this work.;2. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430000 P. R. China These authors contributed equally to this work.;3. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430000 P. R. China |
| Abstract: | DNA nanostructures have recently attracted increasing interest in biological and biomedical applications by virtue of their unique properties, such as structural programmability, multi-functionality, stimuli-responsive behaviors, and excellent biocompatibility. In particular, the intelligent responsiveness of smart DNA nanostructures to specific stimuli has facilitated their extensive development in the field of high-performance biosensing and controllable drug delivery. This minireview begins with different self-assembly strategies for the construction of various DNA nanostructures, followed by the introduction of a variety of stimuli-responsive functional DNA nanostructures for assembling metastable soft materials and for facilitating amplified biosensing. The recent achievements of smart DNA nanostructures for controllable drug delivery are highlighted. Finally, the current challenges and possible developments of this promising research are discussed in the fields of intelligent nanomedicine. |
| Keywords: | DNA drug delivery nanostructures self-assembly stimuli-responsive |