Catalytic Reductive Cross-Coupling between Aromatic Aldehydes and Arylnitriles |
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| Authors: | Atsuhisa Mitsui Dr. Kazunori Nagao Prof. Dr. Hirohisa Ohmiya |
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| Affiliation: | Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University Kakuma-machi, Kanazawa, 920-1192 Japan |
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| Abstract: | A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of α-hydroxy ketones by electrophile–electrophile cross-coupling. |
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| Keywords: | Aldehyde arylnitrile copper α-hydroxy ketone reductive cross-coupling |
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