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Brønsted Acid-Catalysed Dehydrative Substitution Reactions of Alcohols
Authors:Susana Estopiñá-Durán  Dr James E Taylor
Institution:1. Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY UK

EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST UK;2. Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY UK

Abstract:The direct, catalytic dehydrative substitution of alcohols is a challenging, yet highly desirable process in the development of more sustainable approaches to organic chemistry. This review outlines recent advances in Brønsted acid-catalysed dehydrative substitution reactions for C−C, C−O, C−N and C−S bond formation. The wide range of processes that are now accessible using simple alcohols as the formal electrophile are highlighted, while current limitations and therefore possible future directions for research are also discussed.
Keywords:alcohols  Brønsted acid  dehydrative substitution  homogeneous catalysis  sustainable synthesis
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