N,N-Diacylaminals as Emerging Tools in Synthesis: From Peptidomimetics to Asymmetric Catalysis |
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Authors: | Dr Rosa López Prof?Dr Claudio Palomo |
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Institution: | Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco (UPV/EHU), Manuel de Lardizabal 3, 20018 San Sebastián, Spain |
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Abstract: | N,N-Diacylaminals are flexible molecular scaffolds that have commonly been utilized as amide surrogates in peptidomimetics. The singularities of this motif as an N-acyl imine equivalent and as hydrogen-bond donor have recently opened new synthetic opportunities, especially in the field of asymmetric catalysis. This concept article highlights this diverse synthetic potential and provides the elements necessary for further developments. |
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Keywords: | amino acids asymmetric catalysis hydrogen bonds organocatalysis synthetic reactions |
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