Exploiting Transient Radical Cations as Brønsted Acids for Allylic C–H Heteroarylation of Enol Silyl Ethers |
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| Authors: | Dr Tsubasa Nakashima Haruka Fujimori Dr Kohsuke Ohmatsu Prof Takashi Ooi |
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| Institution: | Institute of Transformative Bio-Molecules (WPI-ITbM), and Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, 464-8601 Japan |
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| Abstract: | Intermediary radical cations, generated through single-electron oxidation of enol silyl ethers by excited Ir-based photocatalysts, can be exploited as Brønsted acids for the activation of heteroarylcyanides. This strategy enables the direct allylic C?H heteroarylation of enol silyl ethers under visible-light irradiation. |
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| Keywords: | C?H functionalization enol silyl ethers heteroarylation photoredox catalysis radical cations |
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