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Organophotocatalytic Aerobic Oxygenation of Phenols in a Visible-Light Continuous-Flow Photoreactor |
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| Authors: | Joël Wellauer Dragan Miladinov Thomas Buchholz Dr Jan Schütz Dr René T Stemmler Dr Jonathan A Medlock Dr Werner Bonrath Prof Dr Christof Sparr |
| Institution: | 1. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland
These authors contributed equally to this work.;2. DSM Nutritional Products Ltd., P.O. Box 2676, 4002 Basel, Switzerland;3. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland |
| Abstract: | A mild photocatalytic phenol oxygenation enabled by a continuous-flow photoreactor using visible light and pressurized air is described herein. Products for wide-ranging applications, including the synthesis of vitamins, were obtained in high yields by precisely controlling principal process parameters. The reactor design permits low organophotocatalyst loadings to generate singlet oxygen. It is anticipated that the efficient aerobic phenol oxygenation to benzoquinones and p-quinols contributes to sustainable synthesis. |
| Keywords: | aerobic oxidation phenol photooxygenation singlet oxygen vitamins |