Practical Enzymatic Production of Carbocycles |
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| Authors: | Weijin Wang Prof Dr Douglass F Taber Prof Dr Hans Renata |
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| Institution: | 1. Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 33458 USA;2. Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716 USA |
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| Abstract: | The Pd-catalyzed carbon-carbon bond formation pioneered by Heck in 1969 has dominated medicinal chemistry development for the ensuing fifty years. As the demand for more complex three-dimensional active pharmaceuticals continues to increase, preparative enzyme-mediated assembly, by virtue of its exquisite selectivity and sustainable nature, is poised to provide a practical and affordable alternative for accessing such compounds. In this minireview, we summarize recent state-of-the-art developments in practical enzyme-mediated assembly of carbocycles. When appropriate, background information on the enzymatic transformation is provided and challenges and/or limitations are also highlighted. |
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| Keywords: | alicyclic synthesis biocatalysis carbocycles enzymatic methods medicinal chemistry |
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