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Rhamnogalacturonan II: Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo** |
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| Authors: | Dr Enzo Mancuso Dr Cecilia Romanò Dr Nino Trattnig Dr Philipp Gritsch Dr Paul Kosma Prof Dr Mads H Clausen |
| Institution: | 1. Department of Chemistry, Center for Nanomedicine and Theranostics, Technical University of Denmark, Kemitorvet 207, 2800, Kgs. Lyngby, Denmark;2. Department of Chemistry, University of Natural Resources and Life Sciences, 18 Muthgasse, 1190 Vienna, Austria;3. Institute of Applied Synthetic Chemistry TU Wien, Getreidemarkt 9, 1060 Vienna, Austria |
| Abstract: | The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone, through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor. |
| Keywords: | carbohydrates glycosylation Kdo plant cell wall rhamnogalacturonan |