Rhodium-Catalyzed Chemodivergent Regio- and Enantioselective Allylic Alkylation of Indoles |
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| Authors: | Minghe Sun Min Liu Prof Dr Changkun Li |
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| Institution: | Shanghai Key Laboratory for Molecular Engineering of Chiral, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China |
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| Abstract: | The control of C3/N1 chemoselectivity in indole alkylation with the same electrophiles is still challenging. An Rh/bisoxazolinephosphane-catalyzed chemodivergent regio- and enantioselective allylic alkylation of indoles was developed. Chiral C3- and N1-allylindoles can be selectively obtained with high branched/linear ratio and up to 99 % ee by changing the counteranion of Rh, the allylic carbonate, the reaction temperature, and the ligand. |
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| Keywords: | alkylation asymmetric catalysis chemoselectivity indole rhodium |
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