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Catalytic Enantioselective Isocyanide-Based Reactions: Beyond Passerini and Ugi Multicomponent Reactions
Authors:Jian Luo  Prof Dr Guo-Shu Chen  Dr Shu-Jie Chen  Prof Dr Zhao-Dong Li  Prof Dr Yun-Lin Liu
Institution:1. School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006 P. R. China

These authors contributed equally to this work.;2. School of Chemistry and Chemical Engineering, Guangzhou University, 230 Wai Huan Xi Road, Guangzhou, 510006 P. R. China;3. Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University, Wushan Street five road No. 483, Guangzhou, 510642 P. R. China

Abstract:The development of catalytic enantioselective isocyanide-based reactions is currently of great interest because the resulting products are valuable in organic synthesis, pharmacological chemistry, and materials science. This review assembles and comprehensively summarizes the recent achievements in this rapidly growing area according to the reaction types. Special attention is paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction. In addition, a personal outlook on the opportunities for further exploration is given at the end.
Keywords:[3+2] cycloaddition  cascade reactions  catalytic asymmetric  insertion reaction  isocyanide
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