Synthesis of new C2- symmetric fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in Friedel-Crafts reactions |
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Authors: | Li Jing Chen Hong-Liang Liu Lei Fu Bin |
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Institution: | Department of Applied Chemistry, China Agricultural University, Beijing 100193, China. lijing_19901210@126.com |
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Abstract: | A series of new C(2)-symmetric fluoren-9-ylidene malonate-derived bis(oxazoline) ligands were synthesized from fluoren-9-ylidene malonate and enantiomerically pure amino alcohols via a convenient route. Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl group showed moderate to good enantioselectivity (up to 88% ee). |
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