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Enzymatic synthesis of N-acylethanolamines: direct method for the aminolysis of esters |
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| Authors: | Kyle M WhittenAlexandros Makriyannis Subramanian K Vadivel |
| Institution: | Center for Drug Discovery, Department of Chemistry and Chemical Biology, 116 Mugar Hall, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, USA |
| Abstract: | Immobilized Candida antarctica (Novozyme 435) catalyzed synthesis of N-acylethanolamines is described. Treatment of methyl esters with lipase and amines yielded the desired amides within 2-24 h with yields ranging from 41% to 98%. |
| Keywords: | N-Acylethanolamines Candida antarctica Endogenous ligand Amidation Biocatalysis |
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