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Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida |
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| Authors: | Shi ShenHuajie Zhu Dawei ChenDong Liu Leen van OfwegenPeter Proksch Wenhan Lin |
| Institution: | a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China b Kunming Institute of Botany, CAS, Heilongtan, Kunming 650204, PR China c National Museum of Natural History Naturalis, 2300 RA Leiden, The Netherlands d Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany |
| Abstract: | Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. |
| Keywords: | Soft coral Sinularia pavida Pavidolides A-E Structural elucidation Antifouling activity Cytotoxic activity |
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