| Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes:Application to the synthesis of escitalopram |
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| 作者姓名： | Peng Wang Rui Zhang Jin Cai Jun-Qing Chen Min Ji |
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| 作者单位： | a School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China;
b School of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096, China |
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| 基金项目： | supported by the National Basic Research Program of China(No.2011CB933503);Technology Supporting Program of Jiangsu Province(Nos.BE2009639 and BE2012657) |
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| 摘 要： | An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, oaroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of Naroylhydrazones of salicylaldehydes. The mild and general strategy enables the synthesis of various substituted 1,3-dihydroisobenzofurans in high yields. Moreover, this method can be applied to efficiently synthesize escitalopram.
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| 关 键 词： | 高效合成 水杨醛 西酞普兰 应用 功能化 四乙酸铅 中间体 高收率 |
| 收稿时间： | 11 September 2013 |
Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes： Application to the synthesis of escitalopram |
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| Peng Wang,Rui Zhang,Jin Cai,Jun-Qing Chen,Min Ji.Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes:Application to the synthesis of escitalopram[J].Chinese Chemical Letters,2014,25(4):549-552. |
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| Authors: | Peng Wang Rui Zhang Jin Cai Jun-Qing Chen Min Ji |
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| Institution: | a School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China;
b School of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096, China |
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| Abstract: | An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed.In this novel route,oaroylbenzaldehydes,as key intermediates,can be obtained by lead tetraacetate oxidation of Naroylhydrazones of salicylaldehydes.The mild and general strategy enables the synthesis of various substituted 1,3-dihydroisobenzofurans in high yields.Moreover,this method can be applied to efficiently synthesize escitalopram. |
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| Keywords: | Isobenzofuran Salicylaldehyde Efficient synthesis Escitalopram |
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