| An easy route to exotic 9-epimers of 9-amino-(9-deoxy) cinchona alkaloids with(8S,9R) and(8R,9S)-configurations through two inversions of configuration |
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| 引用本文： | Jing-Wei Wan,Xue-Bing Ma,Rong-Xing He,Ming Li. An easy route to exotic 9-epimers of 9-amino-(9-deoxy) cinchona alkaloids with(8S,9R) and(8R,9S)-configurations through two inversions of configuration[J]. 中国化学快报, 2014, 25(4): 557-560. DOI: 10.1016/j.cclet.2013.12.008 |
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| 作者姓名： | Jing-Wei Wan Xue-Bing Ma Rong-Xing He Ming Li |
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| 作者单位： | College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China |
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| 基金项目： | Research support from the National Science Foundation ofChina(No.21071116);Chongqing Scientific Foundation,China(No.2010BB4126) |
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| 摘 要： | Four exotic chiral organocatalysts, 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）- configurations, were conveniently synthesized for the first time in 27-72% total yields through two conversions of configuration at the 9-stereogenic centers of commercially available cinchona alkaloids.
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| 关 键 词： | 金鸡纳生物碱 差向异构体 配置 氨基 脱氧 倒置 手性中心 有机催化剂 |
| 收稿时间： | 2013-10-08 |
An easy route to exotic 9-epimers of 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）-configurations through two inversions of configuration |
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| 《Chinese Chemical Letters》. An easy route to exotic 9-epimers of 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）-configurations through two inversions of configuration[J]. Chinese Chemical Letters, 2014, 25(4): 557-560. DOI: 10.1016/j.cclet.2013.12.008 |
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| Authors: | 《Chinese Chemical Letters》 |
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| Affiliation: | College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China |
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| Abstract: | Four exotic chiral organocatalysts,9-amino-(9-deoxy) cinchona alkaloids with(8S,9R) and(8R,9S)-configurations,were conveniently synthesized for the first time in 27-72%total yields through two conversions of configuration at the 9-stereogenic centers of commercially available cinchona alkaloids. |
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| Keywords: | Cinchona alkaloids 9-Amino-（9-deoxy） cinchona alkaloids Synthesis Inversion of configuration |
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