A three-component one-pot synthesis of 2-alkoxy-4-amino-N- arylthiazole-5-carboxamides |
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| Authors: | Hai-Long Zhao Jie Zhou Hong-Rui Song Bai-Ling Xu |
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| Affiliation: | a Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;b Department of Pharmacy Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | A facile and efficient protocol was developed to access 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides through a three-component one-pot reaction, which involved potassium methyl cyanimidodithiocarbonate, 2-halo-N-arylacetamides and alcohols. The easy availability and the broad structural diversity of substrates make the reaction useful for the construction of libraries in drug discovery. |
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| Keywords: | 4-Aminothiazole-5-carboxamidePotassium methylcyanimidodithiocarbonateAcetamide |
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