Three new diterpenoids from Leonurus japonicus |
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| Authors: | Zhi-Ke Liu ;Da-Rong Wu ;Yi-Ming Shi ;Ting Zeng ;Shao-Hua Liu ;Xue Du ;Yong-Jun Dang ;Wei-Lie Xiao ;Han-Dong Sun |
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| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Chengdu No. 1 Pharmaceutical Group Co., Ltd., Chengdu 610031, China;
c University of Chinese Academy of Sciences, Beijing 100049, China;
d Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China |
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| Abstract: | Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity. |
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| Keywords: | Leonurus japonicus Leojaponin A Leojaponin B Leojaponin C |
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