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Metalloporphyrin receptors for histidine-containing peptides |
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| Authors: | Hui Liu ;Zhan-Ting Li |
| Institution: | a Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430073, China; b State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China |
| Abstract: | Two new ditopic metalloporphyrin receptors constructed by combining metalloporphyrin with crown ethers have been prepared and characterized.1H NMR and MS spectra confirmed the complexation of receptor with peptide driven by coordination interaction and hydrogen bonding.UV/vis experiments revealed that the receptors exhibited high binding affinity to histidine-containing peptides.These receptors could differentiate short peptides of C-terminal histidine and N-terminal histidine and formed the most stable complexes with tripeptide. |
| Keywords: | Metallop or phyrin Crown ether Synthetic receptor Peptide |
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