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A highly flexible green synthesis of 1H-pyrazolo[1,2-b]phthalazine- 5,10-dione derivatives with CuI nanoparticles as catalyst under solvent-free conditions
Authors:Javad  Safaei-Ghomi Hossein  Shahbazi-Alavi Abolfazl  Ziarati Raheleh  Teymuri Mohammad  Reza Saberi
Institution:Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, Iran
Abstract:CuI nanoparticles as an efficient catalyst have been used for the preparation of 1H-pyrazolo1,2-b]phthalazine-5,10-diones by the four-component condensation reaction of phthalic anhydride, hydrazine monohydrate, aromatic aldehydes and malononitrile or ethyl cyanoacetate under solventfree conditions in good to excellent yields, short reaction times and environmentally benign, milder reaction conditions.
Keywords:NanoparticlesMulti-component reactionsSolvent-freePyrazolophthalazine
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