Studies on New Steroidal Saponins from Allii macrostemonis Bulbus and Their Antitumor Activities |
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Authors: | YAO Hua WANG Tong WU Qian LIU Ying LI Peng LI Xuwen JIN Yongri |
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Affiliation: | 1. Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China; 2. College of Chemistry, Jilin University, Changchun 130012, P. R. China |
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Abstract: | Two new steroidal saponins(2, 3) and two known compounds(1, 4) were isolated from 75% ethanol extract of Allii macrostemonis bulbus by various spectral methods. The two new steroidal saponins were respectively elucidated as (25S)-26-O-β-D-glucopyranosyl-5α-furostanol-2α,3β,22,26-tetrol-3-O-β-D-glucopyranosyl(1→2)-[β-D- glucopyranosyl(1→3)]-β-D-glucopyranosyl(1→4)-β-D-galactopyranoside(2) and 26-O-β-D-glucopyranosyl-5α- furostanol-25(27)-ene-3β,22,26-tetrol-3-O-β-D-glucopyranosyl(1→2)-[β-D-glucopyranosyl(1→3)]-β-D-glucopyranosyl- (1→4)-β-D-galactopyranoside(3). Compound 4 was obtained from this medical plant for the first time. The activity experiments of proliferation inhibition on tumor cells were performed by cell counting kit-8(CCK-8) method for compound 2(25S-configuration) and its isomer(compound 1, 25R-configuration). The results show that compounds 1 and 2 have weak inhibition on lung cancer A549 cells, melanoma A375 cells and breast cancer MCF-7 cells as well as certain inhibitory effect on liver cancer HepG2 cells, and the inhibitory effect of compound 1 is stronger than that of compound 2. |
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Keywords: | Allii macrostemonis bulbus Steroidal saponin Structure identification Proliferation inhibition Cell counting kit-8(CCK-8) method |
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