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Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation |
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| Authors: | Tobias Plümpe Dan Ehninger Barbara Steiner Friederike Klempin Sebastian Jessberger Moritz Brandt Benedikt Römer Gerardo Ramirez Rodriguez Golo Kronenberg Gerd Kempermann |
| Institution: | 1. Max Delbrück Center for Molecular Medicine (MDC), Berlin-Buch, Germany 3. UCLA Medical Center, Departments of Neurobiology, Psychiatry and Psychology, 695 Charles Young Drive South, 90095, Los Angeles, CA, USA 2. Volkswagenstiftung Research Group, Dept. of Experimental Neurology, Charity, University Medicine, Berlin, Germany 4. Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd. La Jolla, 92037, CA, USA 5. Zentralinstitut für Seelische Gesundheit, J5, 68159, Mannheim, Germany |
| Abstract: | BackgroundIn the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on precursor cells or as survival-promoting effect on postmitotic cells. We here obtained quantitative data about the proliferative population and the dynamics of postmitotic dendrite development during the period of DCX expression. The question was, whether any indication could be obtained that the initiation of dendrite development is timely bound to the exit from the cell cycle. Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events. |
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