Abstract: | Chiral C3‐symmetric trialkyl phosphites, derivatives, of (?)‐(1R,2S,5R)‐menthol, and (?)‐di‐O‐isopropylidene‐1,2:5,6‐α‐D ‐glucofuranose, have been studied as starting reagents for the preparation of chiral organophosphorus compounds. The reactions involve induction at the α‐carbon atom of substituted α‐alkylphosphonates. The stereoselectivity of the reaction depends on the structure of the starting compounds and the reaction conditions. The configurations of the alkylphosphonates were defined by means of NMR spectroscopy and by transformation into corresponding alkylphosphonic acids. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:138–143, 2000 |