Effect of microwave heating in the asymmetric addition of dimethylzinc to aldehydes |
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Authors: | Miroslav Genov Gorka Salas Pablo Espinet |
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Affiliation: | aIU CINQUIMA/Química Inorgánica, Facultad de Ciencias, Universidad de Valladolid, 47071 Valladolid, Spain |
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Abstract: | Microwave-heated enantioselective additions of dimethylzinc to various aldehydes are reported. Dramatically reduced reaction times and lower catalyst loadings (5%), compared with conventionally used conditions, can be achieved, with excellent yields and just small loss of enantioselectivity (up to 83% enantioselectivity is achieved). In the reaction with aliphatic aldehydes the same enantioselectivity has been achieved for microwave-heated and conventional room temperature conditions. |
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Keywords: | Addition reactions Asymmetric synthesis Aminoalcohols Microwave Zinc |
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