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A Light-Induced Decarboxylative-Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease |
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| Authors: | Dr Roshni Malde Dr Daniel A Richards Luigia Salerno Yanbo Zhao Dr Kersti Karu Prof Vijay Chudasama Prof James R Baker |
| Institution: | 1. Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK;2. Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK
Contribution: Data curation (supporting), Formal analysis (supporting), ?Investigation (supporting), Methodology (supporting), Writing - review & editing (supporting);3. Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK Contribution: Formal analysis (supporting) |
| Abstract: | Herein we report on photodecarboxylations of various substituted maleimides, resulting in an elimination reaction. Furthermore, we establish facile wavelength tunability through modulation of the maleimide double bond substituents. We envisage that these versatile reagents, which are readily constructed and diversified by nucleophilic substitution reactions on bromomaleimides, will offer new opportunities for triggered photorelease. |
| Keywords: | photodecarboxylation photocleavable linker phototrigger maleimide thiomaleimide |