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Synthesis,Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half-Sandwich Ruthenium and Osmium Complexes |
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| Authors: | Joan J Soldevila-Barreda Andrea Pettenuzzo Maria Azmanova Laia Rafols Amr A A Attia Alexandru Lupan Luca Ronconi Nicolas P E Barry Anaïs Pitto-Barry |
| Institution: | 1. School of Chemistry and Biosciences, University of Bradford, UK-BD7 1DP Bradford, United Kingdom;2. School of Biological and Chemical Sciences, University of Galway, IE-H91 TK33 Galway, Ireland;3. Facultatea de Chimie şi Inginerie Chimică, Universitatea Babeş-Bolyai, RO-400028 Cluj-Napoca, Romania |
| Abstract: | The synthesis by transmetallation and in-depth characterisation by IR spectroscopy of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed. |
| Keywords: | cytotoxicity glycoconjugates half-sandwich metal complexes sandwich complexes |