Stir-bar sorptive extraction based on hydroxyl-functionalized zirconium-metal-organic framework for the detection of three quinolones in actual samples |
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Authors: | Jina Wang Yan Gao Nan Zhang Yundong Xie Xinya Xu Hui Guo Tao Bao Meng Sun Sicen Wang |
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Institution: | 1. College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, P. R. China;2. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, P. R. China
Shaanxi Engineering Research Center of Cardiovascular Drugs Screening and Analysis, Xi'an, P. R. China;3. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, P. R. China |
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Abstract: | A novel analytical method based on stir-bar sorptive extraction was proposed for the determination of three trace quinolones in fish and shrimp samples. UiO-66-(OH)2, a hydroxyl-functionalized zirconium metal-organic framework, has been coated on frosted glass rods by an in situ growth method. The product, UiO-66-(OH)2 modified frosted glass rods, has been characterized and key parameters have been optimized in combination with ultra-high-performance liquid chromatography. The detection limits of enoxacin, norfloxacin, and ciprofloxacin were 0.48–0.8 ng ml−1, and the detection concentrations were in the range of 10–300 ng ml−1, showing a good linear relationship. This method was used for the determination of three quinolones in aquatic organisms, and the recoveries in spiked fish and shrimp muscle tissue samples were 74.8%–105.4% and 82.5%–115.8%, respectively. The relative standard deviations were less than 6.9%. The established method combined stir-bar sorptive extraction based on UiO-66-(OH)2 modified frosted glass rods with ultra-high-performance liquid chromatography, has good application prospects for the detection of quinolone residues in fish and shrimp muscle samples. |
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Keywords: | quinolones stir-bar sorptive extraction UiO-66-(OH)2 ultra-high-performance liquid chromatography |
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