Three Component Synthesis of 4-Aryl-2-aminothiazoles under Transition-Metal Free Conditions |
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| Authors: | Xi Cheng Da-Bin Qin Zhi-Bing Dong |
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| Affiliation: | 1. School of Chemistry and Environmental, Engineering, Wuhan Institute of Technology, Wuhan, 430205 P. R. China;2. Key Laboratory of Chemical Synthesis and Pollution Control of Sichuan Province, School of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002 P. R. China |
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| Abstract: | An efficient three-component synthesis of 4-aryl-2-aminothiazoles was reported. Phenyl-thioureas reacted with 2-bromoacetophenones to form 4-aryl-2-aminothiazoles through cyclization, and the subsequent C−N bonding with benzyl/allyl bromides gave the desired disubstituted thiazoles smoothly. The protocol features transition-metal free, short reaction time, easily available starting materials, good yields and broad substrate scope, showing potential synthetic value for the synthesis of a variety of biologically or pharmaceutically active compounds. |
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| Keywords: | 2-aminothiazoles C−N bond one-pot synthesis transition-metal free |
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