Thermolysis of Geminal Diazido Malonamides: Simple Access to Tetrazoles and Functionalization of In Situ Formed Isocyanates |
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Authors: | Kathrin Bensberg Dr. Kevin A. Kunz Prof. Dr. Stefan F. Kirsch |
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Affiliation: | Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany |
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Abstract: | In recent years, the development of synthetic methods to afford nitrogen-containing heterocycles has become increasingly popular. Among these, tetrazoles – an important class of aromatic heterocycles – are of significant interest for example, in medicinal chemistry serving as important bioisosteres. Herein, we present a method to easily access C-substituted tetrazoles via thermolysis of geminal diazido malonamides. Formation and functionalization of in situ formed isocyanates and corresponding reactions were also studied. |
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Keywords: | azides nitrogen heterocycles synthetic methods tetrazoles thermolysis |
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