New farnesane-type sesquiterpenes,hedychiols A and B 8,9-diacetate,and inhibitors of degranulation in RBL-2H3 cells from the rhizome of Hedychium coronarium |
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| Authors: | Morikawa Toshio Matsuda Hisashi Sakamoto Yasuko Ueda Kazuho Yoshikawa Masayuki |
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| Affiliation: | Kyoto Pharmaceutical University, Kyoto, Japan. |
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| Abstract: | Two new farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, were isolated from the methanolic extract of the fresh rhizome of Hedychium coronarium KOEN. cultivated in Japan. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of isolated constituents on the release of beta-hexosaminidase from RBL-2H3 cells were examined, and hedychilactone A and coronarin D were found to show the inhibitory activity. |
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