Diisopropyl tartrate (E)-γ-(dimethylphenylsilyl)allylboronate, a chiral allylic alcohol β-carbanion equivalent for the enantioselective synthesis of 2-butene-1,4-diols from aldehydes |
| |
| Authors: | William R. Roush and Paul T. Grover |
| |
| Affiliation: | aDepartment of Chemistry, Indiana University, Bloomington, IN 47405 U.S.A. |
| |
| Abstract: | An enantioselective synthesis of 4-substituted (E)-2-buten-1,4-diols is described. The method involves the reaction of aldehydes with the chiral PhMe2Si- substituted allylboronate3 followed by epoxidation (dimethyl dioxirane) and acid catalyzed Petersen rearrangement of the intermediate epoxysilanols. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
