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Cyclocondensation of α-acylacetamidines with esters of 2-fluoro-5-nitrobenzoic and 4-chloro-2-methyl-5-pyrimidinecarboxylic acids |
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| Authors: | D V Dar’in S G Ryazanov S I Selivanov P S Lobanov A A Potekhin |
| Institution: | (1) St. Petersburg State University, 198504 St. Petersburg, Russia |
| Abstract: | The cyclocondensation of α-acylacetamidines with esters of 2-fluoro-5-nitrobenzoic and 4-chloro-2-methyl-5-pyrimidinecarboxylic acids leads to condensed azines. The reaction proceeds chemoselectively such that the α-carbon atom of the amidine replaces the halogen atom in the aromatic ring, while the amino group reacts with the ester group. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 589–594, April, 2008. |
| Keywords: | α -acylacetamidines C N-dinucleophiles aromatic dielectrophiles enediamines 1-isoquinolinones pyrido[4 3-d]pyrimidines aromatic nucleophilic substitution cyclocondensation |
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