| 水中"一锅法"合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃 |
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| 引用本文： | 靳通收,王爱卿,张建设,张伏生,李同双. 水中"一锅法"合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃[J]. 有机化学, 2004, 24(12): 1598-1600 |
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| 作者姓名： | 靳通收 王爱卿 张建设 张伏生 李同双 |
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| 作者单位： | 河北大学化学与环境科学学院,保定,071002 |
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| 基金项目： | 国家自然科学基金，教育部高校骨干教师资助计划，河北省教育厅科研项目 |
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| 摘 要： | 报道了以十二烷基苯磺酸(DBSA)为催化剂,芳醛、丙二腈和5,5-二甲基-1,3-环己二酮为原料于水中一步生成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃.该方法具有产率高、操作简便、对环境友好、催化剂可重复使用等优点.
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| 关 键 词： | 四氢苯并[b]吡喃 十二烷基苯磺酸 水相 |
| 修稿时间： | 2004-03-01 |
One-Pot Synthesis of 2-Amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran in Aqueous Medium |
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| JIN,Tong-Shou WANG,Ai-Qing ZHANG,Jian-She ZHANG,Fu-Sheng LI,Tong-Shuang. One-Pot Synthesis of 2-Amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran in Aqueous Medium[J]. Chinese Journal of Organic Chemistry, 2004, 24(12): 1598-1600 |
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| Authors: | JIN Tong-Shou WANG Ai-Qing ZHANG Jian-She ZHANG Fu-Sheng LI Tong-Shuang |
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| Abstract: | A synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyrans from aromatic aldehyde, malononitrile and 5,5-dimethyl-1,3-dioxocyclohexane using 4-dodecylbenzenesulfonic acid as the catalyst (10 mol%) was described. This method provided several advantages such as high yield, short reaction time, simple work-up procedure and environmental friendliness and the catalyst could be reusable. |
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| Keywords: | tetrahydrobenzo[b]pyran 4-dodecylbenzenesulfonic acid aqueous medium |
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