| 小分子抗原人工合成进展 |
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| 引用本文： | 王建华,张冲.小分子抗原人工合成进展[J].应用化学,2011,28(4):367-375. |
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| 作者姓名： | 王建华 张冲 |
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| 作者单位： | (重庆大学生物工程学院 重庆 400044) |
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| 摘 要： | 小分子免疫分析技术的应用日渐广泛，合成稳定的、具有良好免疫原性的人工抗原是制备单克隆抗体和建立免疫分析方法的前提和关键。 本文对国内外半抗原的设计与合成方法、载体的选择、半抗原与载体的耦联方法等进行了综述，并对小分子抗原人工合成中相关的问题进行了讨论。
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| 关 键 词： | 人工抗原 半抗原 合成 免疫分析 |
| 收稿时间： | 2010-06-24 |
| 修稿时间： | 2010-09-06 |
Recent Progress in Synthetic Methods of Small Molecule Antigen |
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| WANG Jianhua,ZHANG Chong.Recent Progress in Synthetic Methods of Small Molecule Antigen[J].Chinese Journal of Applied Chemistry,2011,28(4):367-375. |
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| Authors: | WANG Jianhua ZHANG Chong |
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| Institution: | (College of Biomedical Engineering,Chongqing University,Chongqing 400044) |
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| Abstract: | With increasing applications of immune assay, the synthesis of artificial antigen with good stability and immunogenic is the key and premise to prepare the antibody and to establish the method for small molecule immune assay. The progress of synthesis and design method of hapten, carrier selection and the couple method of hapten with carrier are reviewed in this paper. In addition, some questions of the synthesis of small molecule artificial antigen were also discussed. |
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| Keywords: | artificial antigen hapten synthesis immune assay |
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