4-取代-2-氨基嘧啶衍生物的合成

含乙酰基的芳杂环类化合物分别与过量40%~50%的N,N-二甲基甲酰胺-二甲基缩醛（DMF-DMA）在回流温度下进行反应，得到相应的中间产物3-(二甲氨基)-1-（取代）-2-丙烯-1-酮，收率为71.2%~85.2%。 所得中间产物在乙醇介质中，在乙醇钠存在下与盐酸胍回流反应5～7 h，制备了14个4-取代-2-氨基嘧啶类化合物，收率达66.6%~86.1%，产物经核磁、质谱、元素分析等进行了表征。

Synthesis of 4-Substituted-2-Amino-pyrimidines

N,N-Dimethylformamide-dimethyl acetal(DMF-DMA) was refluxed with the corresponding aromatic or heterocyclic compounds to prepare the intermediates 3-(dimethylamino)-1-(substituted)prop-2-en-1-one with a yield of 71.2%~85.2%. By refluxing the obtained intermediates with guanidine hydrochloride in ethanol and in the presence of sodium ethoxide, fourteen 4-substituted-2-amino-pyrimidines were obtained in good yield of 66.6%~86.1%. All the products were confirmed by NMR, mass spectrometry, and elemental analysis.