Steric Interactions in Organic Chemistry: Spatial Requirements of Substituents |
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Authors: | Hans F rster,Fritz V gtle |
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Affiliation: | Hans Förster,Fritz Vögtle |
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Abstract: | From the very extensive factual material available on steric interactions in organic chemistry, the present paper reviews the investigations that provide information about the “size” (“spatial requirement”) of the substituents. After an introductory section on the results obtained with the aid of spectroscopic data and by analysis of chemical reactions, attention is turned to conformational processes, including hindered rotation in ethanes, in the biphenyl system, in butadienes, multiply substituted arenes, molecular propellers, and triptycenes. The main emphasis is placed on the explanation of sterically hindered ring inversions in bridged arenes, a class of compounds particularly suitable for the study of steric interactions. The results obtained by variation of the parameters in this system are also discussed with respect to the spatial requirements of organic substituents. |
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Keywords: | Steric hinderance Spatial requirements Substituent effects |
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