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Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian molecule by using curve resolution methods |
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| Authors: | Amigo José Manuel Bastús Neus G Hoen Rob Vázquez-Campos Socorro Varón Miriam Royo Miriam Puntes Victor |
| Institution: | aDepartment of Food Science, Quality & Technology, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK-1958 Copenhagen, Frederiksberg C, Denmark;bInstitut Català de Nanotecnologia, Campus UAB, 08193 Bellaterra, Barcelona, Spain;cCombinatorial Chemistry Unit, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain |
| Abstract: | In this work, the time-dependent conjugation process between a thiolated molecule (with anti-parkinsonian properties) and gold nanoparticles has been monitored and studied by the combined use of fast acquisition Ultra Violet–Visible (UV–Vis) spectra and the ability of Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) technique. From the highly informative kinetic profiles obtained it was possible to extract quantitative and qualitative information of the conjugation process which includes i) time-dependent concentration profiles and pure spectra of species involved on conjugation process, ii) estimation of molecule concentration necessary for the completeness of the conjugation reaction, iii) molecule footprint and iv) free energy of molecule adsorption. |
| Keywords: | Gold nanoparticles Adenosine antagonist Multivariate Curve Resolution-Alternating Least Squares Ultra Violet&ndash Visible spectroscopy Kinetic modeling |
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