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Bench-Top Type In Vivo EPR Spectrometer for Estimating the Renal Reducing Ability of a Rat |
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| Authors: | Hidekatsu Yokoyama Toshiyuki Sato Takaaki Oteki |
| Institution: | 1. Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara, 324-8501, Japan 2. Yamagata Promotional Organization for Industrial Technology, 2-2-1 Matsuei, Yamagata, 990-2473, Japan 3. Yamagata Research Institute of Technology, 2-2-1 Matsuei, Yamagata, 990-2473, Japan 4. Center for Clinical Medicine and Research, International University of Health and Welfare, 537-3 Iguchi, Nasushiobara, 329-2763, Japan |
| Abstract: | A main electromagnet optimized for electron paramagnetic resonance (EPR) measurements of rats by using a surface loop resonator with a loop diameter of 10?mm was designed. The fabricated main electromagnet was ca. 420?mm in diameter, ca. 240?mm in width, and ca. 60?kg in weight. When a static magnetic field of 25?mT was generated at the center of the main electromagnet, its deviation in a sphere space with a diameter of 10?mm was <0.02?mT. In this condition, the temperature elevation on the surface of the magnet was negligible for the measurement time assumed for in vivo study. Using this magnet, a bench-top type in vivo EPR spectrometer could be obtained, which made it possible to perform EPR measurements for estimating the renal reducing ability of a rat. |
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