| THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION |
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| 作者姓名： | 王咏梅 张政朴 王真 孟继本 霍奇 |
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| 作者单位： | Department of Chemistry，Nankai University，Tianjin 300071，China，The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，Nankai University，Tianjin 300071，China，Department of Chemistry，University of Manchester，Manchester M13 9PL，U.K. |
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| 基金项目： | Project supported by State Education Committee Initial Research Crams for Return Scholar and supported by NSFC No 29774012. |
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| 摘 要： | The optical α-amino acids were synthesized under room temperature byalkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phasetransfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiralphase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of theabove intermediates introduced to the final products-optical α-amino acids. This is anew method for the asymmetric synthesis of α-amino acids. The influences of catalyst,temperature, substrates, and organic solvents on the chemical yield and optical purities ofproducts were studied.
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| 关 键 词： | Asymmetric organic synthesis Polymer supported phase transfer catalysts (PS-PTC) α-Amino acids |
| 收稿时间： | 1998-03-15 |
THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION* |
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| WANG Yongmei,ZHANG Zhengpu,WANG Zhen,MENG Jiben,Hodge P..THE ASYMMETRIC SYNTHESIS OF AMINO ACIDS UNDER POLYMER-SUPPORTED PHASE TRANSFER CATALYTIC CONDITION[J].Chinese Journal of Polymer Science,1998,0(4):356-361. |
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| Authors: | WANG Yongmei ZHANG Zhengpu WANG Zhen MENG Jiben Hodge P |
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| Institution: | The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation; Institute of Polymer Chemistry; Nankai University; Tianjin 300071; China Department of Chemistry; University of Manchester; Manchester M13 9PL; U.K. |
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| Abstract: | The optical α-amino acids were synthesized under room temperature byalkylation of N-(diphenyl methylene) glycine t-butyl ester under polymer-supported phasetransfer conditions using polymer-supported cinchonine (or quinine) alkaloids as chiralphase transfer catalysts and dichloromethane as solvent, followed by hydrolysis of theabove intermediates introduced to the final products-optical α-amino acids. This is anew method for the asymmetric synthesis of α-amino acids. The influences of catalyst,temperature,substrates,and organic solvents on the chemical yield and optical purities of products were stydied. |
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| Keywords: | Asymmetric organic synthesis Polymer supported phase transfer catalysts （PS-PTC） α-Amino acids |
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